PLATFORM
Aging: The elephant in the room
The key challenge in age-related therapeutics is separating the irreversible background of aging from the reversible disease mechanisms
Current technologies struggle to
separating
&
aging
disease
PLATFORM
FAQ aging
Why is aging of long-living species practically irreversible?
Why did entropic aging used to be overlooked?
But why do all humans tend to have the same-age related diseases
Gero aims to overcome the challenges of drug discovery for age-related diseases by inverting the starting point of drug discovery from the microscopic, short-time scale to the macroscopic, long-time scale.
OUR SOLUTION
Separating the effects of aging from the mechanisms of diseases in real-world data for in-human target identification
We have leveraged our background in the physics of complex systems to train a very Large generative Model of human Health (LHM) on a dataset of tens of millions longitudinal, real-world medical histories. The model is unsupervised and can predict future health outcomes similarly to how Large Language Models (LLM) anticipate the next word in a sentence. However, unlike LLMs, our models are physics-based and fully interpretable. It allows us to build clinically relevant disease progression models (phenotypes) in real-world human data and only then look for genetic and molecular factors that control them over long periods of time.
Aging
The main driver behind chronic diseases
In-human
target & drug discovery
HOW OUR PLATFORM WORKS
LHM not only decouples irreversible effects of aging from the reversible mechanisms of diseases, but also identifies clusters of diseases with shared biology potentially enabling pipeline-in-a-pill commercial strategy
By integrating LHM with rich molecular data (such as whole-exome sequencing), we unveil novel treatments for chronic age-related diseases both in-house and in collaborations with pharmaceutical companies.
MARKET OPPORTUNITIES
Age-related diseases hold unexplored market potential
FDA-approved therapeutics discovered via human genetics
36
MONOGENIC DISEASES
3
AGE-RELATED
1
INFECTIOUS