Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts ultimate limit of human lifespan
T. Pyrkov, K. Avchaciov, A. Tarkhov, L. Menshikov, A. Gudkov, P. Fedichev
We introduce a novel blood-based biomarker of aging, the dynamic organism state indicator (DOSI). DOSI is associated with frailty and predicts the prospective incidence of age-related diseases and death. Age-related broadening of DOSI distribution is associated with a progressive loss of physiological resilience. Extrapolation suggests that recovery time would diverge at a critical point of 120 – 150 years of age and signifies a fundamental or absolute limit of human lifespan.

Publications of Gero